Low incidence of the immune reconstitution inflammatory syndrome among HIV-infected patients starting antiretroviral therapy in Gabon: a prospective cohort study.
Identifieur interne : 000565 ( Main/Exploration ); précédent : 000564; suivant : 000566Low incidence of the immune reconstitution inflammatory syndrome among HIV-infected patients starting antiretroviral therapy in Gabon: a prospective cohort study.
Auteurs : S. Janssen [Pays-Bas] ; K. Osbak [Pays-Bas] ; R. Holman [Pays-Bas] ; S. Hermans [Pays-Bas] ; A. Moekotte [Pays-Bas] ; M. Knap [Pays-Bas] ; E. Rossatanga [Gabon] ; M. Massinga-Loembe [Gabon] ; A. Alabi [Gabon] ; A. Adegnika [Gabon] ; C. Meenken [Pays-Bas] ; M. Van Vugt [Pays-Bas] ; P G Kremsner [Gabon] ; G. Meintjes [Afrique du Sud] ; T. Van Der Poll [Pays-Bas] ; M P Grobusch [Pays-Bas]Source :
- Infection [ 1439-0973 ] ; 2017.
Abstract
There is a paucity of data on the immune reconstitution inflammatory syndrome (IRIS) in the Central African region. We followed ART-naive HIV-infected patients initiating antiretroviral therapy in an HIV clinic in Gabon, for 6 months. Among 101 patients, IRIS was diagnosed in five. All IRIS cases were mucocutaneous manifestations. There were no cases of tuberculosis (TB) IRIS, but active TB (n = 20) was associated with developing other forms of IRIS (p = 0.02). Six patients died. The incidence of IRIS is low in Gabon, with mild, mucocutaneous manifestations.
DOI: 10.1007/s15010-017-1000-9
PubMed: 28349491
Affiliations:
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Janssen</name><affiliation wicri:level="4"><nlm:affiliation>Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands. s.janssen@amc.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Osbak, K" sort="Osbak, K" uniqKey="Osbak K" first="K" last="Osbak">K. 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Hermans</name><affiliation wicri:level="4"><nlm:affiliation>Department of Global Health, Academic Medical Center, Amsterdam Institute for Global Health and Development, University of Amsterdam, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Global Health, Academic Medical Center, Amsterdam Institute for Global Health and Development, University of Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Moekotte, A" sort="Moekotte, A" uniqKey="Moekotte A" first="A" last="Moekotte">A. Moekotte</name><affiliation wicri:level="4"><nlm:affiliation>Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Knap, M" sort="Knap, M" uniqKey="Knap M" first="M" last="Knap">M. Knap</name><affiliation wicri:level="4"><nlm:affiliation>Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Rossatanga, E" sort="Rossatanga, E" uniqKey="Rossatanga E" first="E" last="Rossatanga">E. Rossatanga</name><affiliation wicri:level="1"><nlm:affiliation>Centre de Traitement Ambulatoire Lambaréné, Lambaréné, Gabon.</nlm:affiliation><country xml:lang="fr">Gabon</country><wicri:regionArea>Centre de Traitement Ambulatoire Lambaréné, Lambaréné</wicri:regionArea><wicri:noRegion>Lambaréné</wicri:noRegion></affiliation></author><author><name sortKey="Massinga Loembe, M" sort="Massinga Loembe, M" uniqKey="Massinga Loembe M" first="M" last="Massinga-Loembe">M. Massinga-Loembe</name><affiliation wicri:level="1"><nlm:affiliation>Centre de Recherches Médicales en Lambaréné, Lambaréné, Gabon.</nlm:affiliation><country xml:lang="fr">Gabon</country><wicri:regionArea>Centre de Recherches Médicales en Lambaréné, Lambaréné</wicri:regionArea><wicri:noRegion>Lambaréné</wicri:noRegion></affiliation></author><author><name sortKey="Alabi, A" sort="Alabi, A" uniqKey="Alabi A" first="A" last="Alabi">A. Alabi</name><affiliation wicri:level="1"><nlm:affiliation>Centre de Recherches Médicales en Lambaréné, Lambaréné, Gabon.</nlm:affiliation><country xml:lang="fr">Gabon</country><wicri:regionArea>Centre de Recherches Médicales en Lambaréné, Lambaréné</wicri:regionArea><wicri:noRegion>Lambaréné</wicri:noRegion></affiliation></author><author><name sortKey="Adegnika, A" sort="Adegnika, A" uniqKey="Adegnika A" first="A" last="Adegnika">A. Adegnika</name><affiliation wicri:level="1"><nlm:affiliation>Centre de Traitement Ambulatoire Lambaréné, Lambaréné, Gabon.</nlm:affiliation><country xml:lang="fr">Gabon</country><wicri:regionArea>Centre de Traitement Ambulatoire Lambaréné, Lambaréné</wicri:regionArea><wicri:noRegion>Lambaréné</wicri:noRegion></affiliation></author><author><name sortKey="Meenken, C" sort="Meenken, C" uniqKey="Meenken C" first="C" last="Meenken">C. Meenken</name><affiliation wicri:level="3"><nlm:affiliation>Department of Ophthalmology, VU Medical Center, Vrije Universiteit, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, VU Medical Center, Vrije Universiteit, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Van Vugt, M" sort="Van Vugt, M" uniqKey="Van Vugt M" first="M" last="Van Vugt">M. Van Vugt</name><affiliation wicri:level="4"><nlm:affiliation>Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Kremsner, P G" sort="Kremsner, P G" uniqKey="Kremsner P" first="P G" last="Kremsner">P G Kremsner</name><affiliation wicri:level="1"><nlm:affiliation>Centre de Recherches Médicales en Lambaréné, Lambaréné, Gabon.</nlm:affiliation><country xml:lang="fr">Gabon</country><wicri:regionArea>Centre de Recherches Médicales en Lambaréné, Lambaréné</wicri:regionArea><wicri:noRegion>Lambaréné</wicri:noRegion></affiliation></author><author><name sortKey="Meintjes, G" sort="Meintjes, G" uniqKey="Meintjes G" first="G" last="Meintjes">G. Meintjes</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town</wicri:regionArea><wicri:noRegion>Cape Town</wicri:noRegion></affiliation></author><author><name sortKey="Van Der Poll, T" sort="Van Der Poll, T" uniqKey="Van Der Poll T" first="T" last="Van Der Poll">T. Van Der Poll</name><affiliation wicri:level="4"><nlm:affiliation>Division of Internal Medicine, Department of Infectious Diseases, Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Division of Internal Medicine, Department of Infectious Diseases, Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Grobusch, M P" sort="Grobusch, M P" uniqKey="Grobusch M" first="M P" last="Grobusch">M P Grobusch</name><affiliation wicri:level="4"><nlm:affiliation>Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28349491</idno><idno type="pmid">28349491</idno><idno type="doi">10.1007/s15010-017-1000-9</idno><idno type="wicri:Area/PubMed/Corpus">000D20</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D20</idno><idno type="wicri:Area/PubMed/Curation">000D20</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000D20</idno><idno type="wicri:Area/PubMed/Checkpoint">000D20</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000D20</idno><idno type="wicri:Area/Ncbi/Merge">003F63</idno><idno type="wicri:Area/Ncbi/Curation">003F63</idno><idno type="wicri:Area/Ncbi/Checkpoint">003F63</idno><idno type="wicri:Area/Main/Merge">000565</idno><idno type="wicri:Area/Main/Curation">000565</idno><idno type="wicri:Area/Main/Exploration">000565</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Low incidence of the immune reconstitution inflammatory syndrome among HIV-infected patients starting antiretroviral therapy in Gabon: a prospective cohort study.</title><author><name sortKey="Janssen, S" sort="Janssen, S" uniqKey="Janssen S" first="S" last="Janssen">S. Janssen</name><affiliation wicri:level="4"><nlm:affiliation>Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands. s.janssen@amc.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Osbak, K" sort="Osbak, K" uniqKey="Osbak K" first="K" last="Osbak">K. Osbak</name><affiliation wicri:level="4"><nlm:affiliation>Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Holman, R" sort="Holman, R" uniqKey="Holman R" first="R" last="Holman">R. Holman</name><affiliation wicri:level="4"><nlm:affiliation>Clinical Research Unit, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Clinical Research Unit, Academic Medical Center, University of Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Hermans, S" sort="Hermans, S" uniqKey="Hermans S" first="S" last="Hermans">S. Hermans</name><affiliation wicri:level="4"><nlm:affiliation>Department of Global Health, Academic Medical Center, Amsterdam Institute for Global Health and Development, University of Amsterdam, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Global Health, Academic Medical Center, Amsterdam Institute for Global Health and Development, University of Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Moekotte, A" sort="Moekotte, A" uniqKey="Moekotte A" first="A" last="Moekotte">A. Moekotte</name><affiliation wicri:level="4"><nlm:affiliation>Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Knap, M" sort="Knap, M" uniqKey="Knap M" first="M" last="Knap">M. Knap</name><affiliation wicri:level="4"><nlm:affiliation>Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Rossatanga, E" sort="Rossatanga, E" uniqKey="Rossatanga E" first="E" last="Rossatanga">E. Rossatanga</name><affiliation wicri:level="1"><nlm:affiliation>Centre de Traitement Ambulatoire Lambaréné, Lambaréné, Gabon.</nlm:affiliation><country xml:lang="fr">Gabon</country><wicri:regionArea>Centre de Traitement Ambulatoire Lambaréné, Lambaréné</wicri:regionArea><wicri:noRegion>Lambaréné</wicri:noRegion></affiliation></author><author><name sortKey="Massinga Loembe, M" sort="Massinga Loembe, M" uniqKey="Massinga Loembe M" first="M" last="Massinga-Loembe">M. Massinga-Loembe</name><affiliation wicri:level="1"><nlm:affiliation>Centre de Recherches Médicales en Lambaréné, Lambaréné, Gabon.</nlm:affiliation><country xml:lang="fr">Gabon</country><wicri:regionArea>Centre de Recherches Médicales en Lambaréné, Lambaréné</wicri:regionArea><wicri:noRegion>Lambaréné</wicri:noRegion></affiliation></author><author><name sortKey="Alabi, A" sort="Alabi, A" uniqKey="Alabi A" first="A" last="Alabi">A. Alabi</name><affiliation wicri:level="1"><nlm:affiliation>Centre de Recherches Médicales en Lambaréné, Lambaréné, Gabon.</nlm:affiliation><country xml:lang="fr">Gabon</country><wicri:regionArea>Centre de Recherches Médicales en Lambaréné, Lambaréné</wicri:regionArea><wicri:noRegion>Lambaréné</wicri:noRegion></affiliation></author><author><name sortKey="Adegnika, A" sort="Adegnika, A" uniqKey="Adegnika A" first="A" last="Adegnika">A. Adegnika</name><affiliation wicri:level="1"><nlm:affiliation>Centre de Traitement Ambulatoire Lambaréné, Lambaréné, Gabon.</nlm:affiliation><country xml:lang="fr">Gabon</country><wicri:regionArea>Centre de Traitement Ambulatoire Lambaréné, Lambaréné</wicri:regionArea><wicri:noRegion>Lambaréné</wicri:noRegion></affiliation></author><author><name sortKey="Meenken, C" sort="Meenken, C" uniqKey="Meenken C" first="C" last="Meenken">C. Meenken</name><affiliation wicri:level="3"><nlm:affiliation>Department of Ophthalmology, VU Medical Center, Vrije Universiteit, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, VU Medical Center, Vrije Universiteit, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Van Vugt, M" sort="Van Vugt, M" uniqKey="Van Vugt M" first="M" last="Van Vugt">M. Van Vugt</name><affiliation wicri:level="4"><nlm:affiliation>Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Kremsner, P G" sort="Kremsner, P G" uniqKey="Kremsner P" first="P G" last="Kremsner">P G Kremsner</name><affiliation wicri:level="1"><nlm:affiliation>Centre de Recherches Médicales en Lambaréné, Lambaréné, Gabon.</nlm:affiliation><country xml:lang="fr">Gabon</country><wicri:regionArea>Centre de Recherches Médicales en Lambaréné, Lambaréné</wicri:regionArea><wicri:noRegion>Lambaréné</wicri:noRegion></affiliation></author><author><name sortKey="Meintjes, G" sort="Meintjes, G" uniqKey="Meintjes G" first="G" last="Meintjes">G. Meintjes</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town</wicri:regionArea><wicri:noRegion>Cape Town</wicri:noRegion></affiliation></author><author><name sortKey="Van Der Poll, T" sort="Van Der Poll, T" uniqKey="Van Der Poll T" first="T" last="Van Der Poll">T. Van Der Poll</name><affiliation wicri:level="4"><nlm:affiliation>Division of Internal Medicine, Department of Infectious Diseases, Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Division of Internal Medicine, Department of Infectious Diseases, Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Grobusch, M P" sort="Grobusch, M P" uniqKey="Grobusch M" first="M P" last="Grobusch">M P Grobusch</name><affiliation wicri:level="4"><nlm:affiliation>Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author></analytic><series><title level="j">Infection</title><idno type="eISSN">1439-0973</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There is a paucity of data on the immune reconstitution inflammatory syndrome (IRIS) in the Central African region. We followed ART-naive HIV-infected patients initiating antiretroviral therapy in an HIV clinic in Gabon, for 6 months. Among 101 patients, IRIS was diagnosed in five. All IRIS cases were mucocutaneous manifestations. There were no cases of tuberculosis (TB) IRIS, but active TB (n = 20) was associated with developing other forms of IRIS (p = 0.02). Six patients died. The incidence of IRIS is low in Gabon, with mild, mucocutaneous manifestations.</div></front></TEI><affiliations><list><country><li>Afrique du Sud</li><li>Gabon</li><li>Pays-Bas</li></country><region><li>Hollande-Septentrionale</li></region><settlement><li>Amsterdam</li></settlement><orgName><li>Université d'Amsterdam</li></orgName></list><tree><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Janssen, S" sort="Janssen, S" uniqKey="Janssen S" first="S" last="Janssen">S. Janssen</name></region><name sortKey="Grobusch, M P" sort="Grobusch, M P" uniqKey="Grobusch M" first="M P" last="Grobusch">M P Grobusch</name><name sortKey="Hermans, S" sort="Hermans, S" uniqKey="Hermans S" first="S" last="Hermans">S. Hermans</name><name sortKey="Holman, R" sort="Holman, R" uniqKey="Holman R" first="R" last="Holman">R. Holman</name><name sortKey="Knap, M" sort="Knap, M" uniqKey="Knap M" first="M" last="Knap">M. Knap</name><name sortKey="Meenken, C" sort="Meenken, C" uniqKey="Meenken C" first="C" last="Meenken">C. Meenken</name><name sortKey="Moekotte, A" sort="Moekotte, A" uniqKey="Moekotte A" first="A" last="Moekotte">A. Moekotte</name><name sortKey="Osbak, K" sort="Osbak, K" uniqKey="Osbak K" first="K" last="Osbak">K. Osbak</name><name sortKey="Van Der Poll, T" sort="Van Der Poll, T" uniqKey="Van Der Poll T" first="T" last="Van Der Poll">T. Van Der Poll</name><name sortKey="Van Vugt, M" sort="Van Vugt, M" uniqKey="Van Vugt M" first="M" last="Van Vugt">M. Van Vugt</name></country><country name="Gabon"><noRegion><name sortKey="Rossatanga, E" sort="Rossatanga, E" uniqKey="Rossatanga E" first="E" last="Rossatanga">E. Rossatanga</name></noRegion><name sortKey="Adegnika, A" sort="Adegnika, A" uniqKey="Adegnika A" first="A" last="Adegnika">A. Adegnika</name><name sortKey="Alabi, A" sort="Alabi, A" uniqKey="Alabi A" first="A" last="Alabi">A. Alabi</name><name sortKey="Kremsner, P G" sort="Kremsner, P G" uniqKey="Kremsner P" first="P G" last="Kremsner">P G Kremsner</name><name sortKey="Massinga Loembe, M" sort="Massinga Loembe, M" uniqKey="Massinga Loembe M" first="M" last="Massinga-Loembe">M. Massinga-Loembe</name></country><country name="Afrique du Sud"><noRegion><name sortKey="Meintjes, G" sort="Meintjes, G" uniqKey="Meintjes G" first="G" last="Meintjes">G. Meintjes</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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